Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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5,986 – 6,000 of 178,527 results

5,986

Medchemexpress LLC LY3509754 | 2452464-73-0 | 99.4% | 586.51 | 100 MG

LY3509754, also known as IL-17A inhibitor 1, is a potent IL-17A inhibitor with demonstrated IC50 values of less than 9.45 nM in alphalisa assay and 9.3 nM in HT-29 cells. It exhibits high oral bioavailability (F=107%), making it a promising candidate for research.

Potent IL-17A inhibitor
High oral bioavailability (F=107%)
Effective in alphalisa assay and HT-29 cells
Supplied as 100 MG

Pricing & Availability

5,987

Medchemexpress LLC Lunresertib | 2719793-90-3 | 100.0% | C18H20N4O2 | 1 ML

Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM. It demonstrates high selectivity over other kinases in cellular binding assays and exhibits anticancer effects by inducing pan-γH2AX in HCC1569 breast cancer cell lines, making them vulnerable to DNA damage. Lunresertib also causes unscheduled activation of CDK1 in CCNE1-overexpressing cells, promoting early mitosis.

Potent and selective PKMYT1 inhibitor
Orally active with an IC50 of 14 nM
High selectivity over other kinases in cellular binding assays
Exhibits anticancer effects
Induces pan-γH2AX in HCC1569 breast cancer cell line
Causes unscheduled activation of CDK1 in CCNE1-overexpressing cells

Pricing & Availability

5,988

Medchemexpress LLC Piperacillin | 61477-96-1 | 98.1% | 1 ML

Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic. It exhibits potent bactericidal activity against Gram-negative bacteria and selected Gram-positive strains by targeting penicillin-binding proteins. It is commonly combined with the β-lactamase inhibitor Tazobactam for enhanced efficacy.

Semisynthetic broad-spectrum β-lactam antibiotic
Potent bactericidal activity against Gram-negative bacteria
Effective against selected Gram-positive strains
Functions by targeting penicillin-binding proteins
Frequently used in combination with β-lactamase inhibitors
Demonstrates in vitro inhibition against various bacteria including Pseudomonas aeruginosa and Escherichia coli
Prolongs survival in animal models of infection when combined with Tazobactam

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5,989

eMolecules 330645-87-9 | HCTU | Combi-Blocks | MFCD04973268 | 413.690 | C11H15ClF6N5OP | 98.000 | F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccc(Cl)cc12)=[N+](C)C | 5g | 117535827

HCTU | Combi-Blocks | 330645-87-9 | MFCD04973268 | 413.690 | C11H15ClF6N5OP | 98.000 | F[P-](F)(F)(F)(F)F.CN(C)C(On1nnc2ccc(Cl)cc12)=[N+](C)C | 5g | 117535827

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5,990

Medchemexpress LLC CC-671 | 1618658-88-0 | 99.1% | 512.56 | 1 ML

CC-671 is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor, demonstrating potent inhibitory activity against both enzymes. It exhibits cytotoxicity against human BT474 and CAL51 cells and shows significant tumor growth inhibition in vivo. This compound also selectively binds to kinases such as CLK2, CAMKK2, PIP4K22, and JNK.

Dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor
Exhibits cytotoxicity against human BT474 and CAL51 cells
Demonstrates significant tumor growth inhibition in vivo
Selectively binds to CLK2, CAMKK2, PIP4K22, and JNK

Pricing & Availability

5,991

Medchemexpress LLC (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide | 1613465-33-0 | 99.7% | 367.40 g/mol | C19H21N5O3 | 5 MG

ML336 is a quinazolinone-based small-molecule inhibitor of Venezuelan equine encephalitis virus (VEEV) that potently inhibits VEEV-induced cytopathic effects in multiple strains in the low-nanomolar range. It is supplied for research use only and is typically provided as a powder for biochemical and antiviral assays.

Potent VEEV inhibitor exhibiting low-nanomolar antiviral activity.
Quinazolinone-based small molecule for antiviral research and probe development.
High purity (≈99.65%) for consistent experimental results.
Available in small mass vials suitable for screening and assay optimization.
Powder stable at -20°C for long-term storage; solutions stable at -80°C.
Intended for research use only; not for human or veterinary use.

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5,992

Medchemexpress LLC CP-316819 | 186392-43-8 | 99.0% | 415.87 | 100 MG

CP-316819 is a potent glycogen phosphorylase (GPase) inhibitor with antihyperglycemic effect. It has IC50 values of 17 nM against human skeletal muscle glycogen phosphorylase (huSMGPa) and 34 nM against liver glycogen phosphorylase (huLGPa). CP-316819 causes glycogen accumulation under normoglycemic conditions but permits glycogen utilization when glucose concentrations are low. It also prevents neuronal cell death and maintains brain electrical currents.

Molecular weight: 415.87
Formula: C21H22ClN3O4
Appearance: Solid
Color: White to off-white

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5,993

Apexbio Technology LLC Triciribine 35943-35-2 50mg

Triciribine also known as API-2 is a selective inhibitor of Akt kinase activity targeting Akt1 Akt2 and Akt3 without affecting upstream regulators PDK1 and PI3K It suppresses Akt phosphorylation at Thr308 and Ser473 sites triggering apoptosis and growth inhibition in multiple cancer cell models with an IC50 of approximately 130 nM Additionally Triciribine exhibits antiviral activity against HIV-1 inhibiting viral replication and syncytia formation at an IC50 of 20 nM In biomedical research Triciribine is employed to investigate Akt-associated signaling pathways and evaluate potential therapeutic strategies targeting Akt-dependent tumors and HIV infections

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5,994

Medchemexpress LLC MS023 | 1831110-54-3 | 99.9% | 287.40 | 100 MG

MS023 is a chemical probe and a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs), with IC50s of 30, 119, 83, 4, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8. It is utilized for research in epigenetics, particularly in studies involving histone methyltransferases, and demonstrates antiproliferative effects against human A549, HCC4006, and SK-LU-1 cells.

Potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs)
Inhibits PRMT1 methyltransferase activity in MCF7 cells
Inhibits PRMT6 methyltransferase activity in HEK293 cells
Blocks MLL-r acute lymphoblastic leukemia (ALL) propagation in animal models
Extends survival of leukemic mice in combination treatments

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5,995

Medchemexpress LLC NNC 63-0532 | 50MG

NNC 63-0532 | 50MG

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5,996

Cayman Chemical SBromoenol lactoned7

An internal standard for the quantification of (S)-BEL by GC- or LC-MS

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5,997

Medchemexpress LLC 3-hydroxypropionic acid-13C3 sodium | 115.04 | 13C3H5NaO3 | 500ug

3-Hydroxypropionic acid-13C3 sodium is the 13C labeled 3-Hydroxypropionic acid sodium (HY-W095705A) 3-Hydroxypropionic acid sodium an endogenous metabolite is a building block in the chemical synthesis[1]

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5,998

Medchemexpress LLC GE11 | 875142-25-9 | 99.6% | 1540.68 | 100 MG

GE11 is an active peptide suitable for cancer studies and targeted drug delivery. It acts as a smart carrier for antitumor drugs by combining with colloidal drug delivery systems. As a potent EGFR ligand, this dodecapeptide specifically binds to EGFR with high affinity and selectivity, making it valuable for the diagnosis and targeted delivery of drugs in radiotherapy, gene therapy, and chemotherapy against EGFR-positive tumors.

Active peptide for cancer studies
Combines with colloidal drug delivery systems as smart carriers
Potent EGFR ligand with high affinity and selectivity
Used in diagnosis and targeted drug delivery
Applicable for radiotherapy, gene therapy, and chemotherapy against EGFR-positive tumors

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5,999

Medchemexpress LLC PF-4989216 | 1276553-09-3 | 99.4% | 380.40 | 50 MG

PF-4989216 is a potent and selective PI3Kα inhibitor with a Ki of 0.6 nM. It is for research use only.

Potent and selective PI3Kα inhibitor (Ki of 0.6 nM)
Excellent selectivity against mTOR (Ki=1440 nM) and other kinases
Demonstrates dose-responsive tumor growth inhibitory activity in xenograft models
Available as white to off-white solid
Suitable for research use only

Pricing & Availability

6,000

Medchemexpress LLC WAY-600 | 1062159-35-6 | MFCD22419019 | C28H30N8O | 50 MG

WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for the recombinant mTOR enzyme. It effectively blocks mTOR complex 1/2 (mTORC1/2) assembly and activation, demonstrating significant anti-cancer activity in vitro against HepG2 and Huh-7 cells and in vivo by inhibiting HepG2 tumor growth in nude mice.

Potent, ATP-competitive, and selective mTOR inhibitor
Blocks mTOR complex 1/2 assembly and activation
Inhibits HepG2 and Huh-7 cell viability
Decreases HepG2 cell colonies
Increases caspase-3 and caspase-9 activity in HepG2 cells
Inhibits HepG2 tumor growth in nude mice

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Pyridines and derivatives

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Medchemexpress LLC LY3509754 | 2452464-73-0 | 99.4% | 586.51 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lunresertib | 2719793-90-3 | 100.0% | C18H20N4O2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Piperacillin | 61477-96-1 | 98.1% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CC-671 | 1618658-88-0 | 99.1% | 512.56 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide | 1613465-33-0 | 99.7% | 367.40 g/mol | C19H21N5O3 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CP-316819 | 186392-43-8 | 99.0% | 415.87 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Triciribine 35943-35-2 50mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MS023 | 1831110-54-3 | 99.9% | 287.40 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NNC 63-0532 | 50MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Cayman Chemical SBromoenol lactoned7 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3-hydroxypropionic acid-13C3 sodium | 115.04 | 13C3H5NaO3 | 500ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GE11 | 875142-25-9 | 99.6% | 1540.68 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PF-4989216 | 1276553-09-3 | 99.4% | 380.40 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC WAY-600 | 1062159-35-6 | MFCD22419019 | C28H30N8O | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More